Short small-interfering RNAs produce interferon-α-mediated analgesia
نویسندگان
چکیده
منابع مشابه
Short small-interfering RNAs produce interferon-α-mediated analgesia.
BACKGROUND There is increasing interest in RNA interference in pain research using the intrathecal route to deliver small-interfering RNA (siRNA). An interferon (IFN) response is a common side-effect of siRNA. However, the IFN response in the spinal cord after intrathecal administration of siRNA remains unknown. We hypothesized that high doses of siRNAs can elicit off-target analgesia via relea...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2012
ISSN: 0007-0912
DOI: 10.1093/bja/aer492